Toxic epidermal necrosis - I-Epidermal Necrosis Enobuthi
☆ Emiphumeleni ka-2022 ye-Stiftung Warentest evela eJalimane, ukwaneliseka kwabathengi nge-ModelDerm bekungaphansi kancane kunokuxhumana okukhokhelwayo kwe-telemedicine.
Isici sokulahleka kwesikhumba kwe-I-Epidermal Necrosis Enobuthi (Toxic epidermal necrosis)
References
I- Stevens-Johnson Syndrome (SJS) kanye ne- Toxic Epidermal Necrolysis (TEN) yizimo ezingavamile lapho isikhumba sithola i-necrosis eningi kanye nokuchitheka. Mayelana nokwelashwa, i-cyclosporine iphumelela kakhulu ku-SJS, kuyilapho inhlanganisela ye-intravenous immunoglobulin (IVIg) kanye ne-corticosteroids isebenza kangcono kakhulu ezimweni ze-SJS ne-TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) ukusabela kwesikhumba okungathi sína okubangelwa imithi ethile nokusebenza kwamasosha omzimba, okuholela ekuhlukanisekeni okukhulu kongqimba lwesikhumba olungaphandle (i-epidermis) , okuthinta ngaphezu kuka-30% wobuso bomzimba. I-TEN inezinga lokufa elingaphezu kwama-20%, ngokuvamile ngenxa yezifo kanye nobunzima bokuphefumula. Ukumisa imithi ebangela ukusabela, ukunikeza ukunakekelwa okusekelayo, nokusebenzisa imithi eyengeziwe kungathuthukisa umphumela. Ucwaningo lwakamuva lubonise ukuthi izidakamizwa ezifana ne-cyclosporine, i-tumor necrosis factor alpha inhibitors, kanye nenhlanganisela ye-immune globulin ne-corticosteroids ingaba usizo, ngokusekelwe ekuhlolweni okulawulwa ngokungahleliwe kanye nokuhlaziywa kwezifundo eziningi.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Isizathu esivame kakhulu imithi ethile efana ne-lamotrigine, i-carbamazepine, i-allopurinol, ama-antibiotic e-sulfonamide, ne-nevirapine. Izinto eziyingozi zihlanganisa i-HIV kanye ne-systemic lupus erythematosus. Ukwelashwa ngokuvamile kwenzeka esibhedlela njengasegunjini lokusha noma egunjini labagula kakhulu.
○ Ukwelashwa
Lesi yisifo esibi kakhulu, ngakho-ke uma izindebe zakho noma umlomo wakho kuthintekile noma isikhumba sakho siba namabhamuza, bonana nodokotela wakho ngokushesha ngangokunokwenzeka.
Izidakamizwa ezisolisayo kufanele ziyekwe. (isb. ama-antibiotics, ama-non-steroidal anti-inflammatory drugs)